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Transglutaminase type 2 plays a key role in the pathogenesis of Mycobacterium tuberculosis infection

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Mycobacterium tuberculosis (MTB), the aetiological agent of tuberculosis (TB), is capable of interfering with the phagosome maturation pathway, by inhibiting phagosome–lysosome fusion and the autophagic process to ensure survival and… Click to show full abstract

Mycobacterium tuberculosis (MTB), the aetiological agent of tuberculosis (TB), is capable of interfering with the phagosome maturation pathway, by inhibiting phagosome–lysosome fusion and the autophagic process to ensure survival and replication in macrophages. Thus, it has been proposed that the modulation of autophagy may represent a therapeutic approach to reduce MTB viability by enhancing its clearance.

Keywords: type plays; transglutaminase type; tuberculosis; plays key; mycobacterium tuberculosis

Journal Title: Journal of Internal Medicine
Year Published: 2018

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