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Optimal dosing of zoledronate to prevent fractures: improving risk‐benefit balance

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In their prospective, randomized, placebo-controlled, double-blind trial that investigated anti-fracture efficacy of zoledronate in a total of 2000 osteopenic postmenopausal women aged over 65 years, Reid et al. [1, 2] provides… Click to show full abstract

In their prospective, randomized, placebo-controlled, double-blind trial that investigated anti-fracture efficacy of zoledronate in a total of 2000 osteopenic postmenopausal women aged over 65 years, Reid et al. [1, 2] provides crucial evidence that is highly useful for clinical practice; intravenous administration of zoledronate at a dose of 5 mg every 18 months for 6 years reduced fracture risk independently of baseline clinical characteristics including age, dietary calcium intake, and recent falls history. This article is protected by copyright. All rights reserved.

Keywords: optimal dosing; risk; zoledronate; dosing zoledronate; zoledronate prevent; prevent fractures

Journal Title: Journal of Internal Medicine
Year Published: 2019

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