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Is acid suppression associated with the increased length of stay in diabetic ketoacidosis patients? A nationwide analysis

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Diabetic ketoacidosis (DKA) patients present with low serum bicarbonate ( HCO3−${\rm{HCO}}_{3}^{-} $ ), and an increase in its level to ≥15 mEq/L is considered one of the criteria for DKA… Click to show full abstract

Diabetic ketoacidosis (DKA) patients present with low serum bicarbonate ( HCO3−${\rm{HCO}}_{3}^{-} $ ), and an increase in its level to ≥15 mEq/L is considered one of the criteria for DKA resolution. Both proton pump inhibitors and histamine‐2 receptor antagonists inhibit downstream functioning of H+/K+ ATPase in the gastric parietal cells, which results in the decreased secretion of HCO3−${\rm{HCO}}_{3}^{-} $ into the bloodstream.

Keywords: acid suppression; associated increased; diabetic ketoacidosis; increased length; ketoacidosis; suppression associated

Journal Title: Journal of Internal Medicine
Year Published: 2022

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