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Epidemiological studies consistently find low concentrations of 25‐hydroxyvitamin D (25(OH)D) in blood to be associated with increased mortality, and a recent large‐scale Mendelian randomization study strongly supports a causal relationship… Click to show full abstract
Epidemiological studies consistently find low concentrations of 25‐hydroxyvitamin D (25(OH)D) in blood to be associated with increased mortality, and a recent large‐scale Mendelian randomization study strongly supports a causal relationship among individuals with low vitamin D status. Evolving evidence suggested that bioavailable or free 25(OH)D may better predict mortality. We aimed to compare the prognostic values of vitamin D–binding protein (VDBP), total, bioavailable, complementary “nonbioavailable”, and free 25(OH)D for total and cause‐specific mortality in a large population‐based cohort study of older adults from Germany.
Journal Title: Journal of Internal Medicine
Year Published: 2022
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