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Metabolomic markers mediate erythrocyte anisocytosis in older adults: Results from three independent aging cohorts

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Anisocytosis reflects unequal‐sized red blood cells and is quantified using red blood cell distribution width (RDW). RDW increases with age and has been consistently associated with adverse health outcomes, such… Click to show full abstract

Anisocytosis reflects unequal‐sized red blood cells and is quantified using red blood cell distribution width (RDW). RDW increases with age and has been consistently associated with adverse health outcomes, such as cardiovascular disease and mortality. Why RDW increases with age is not understood. We aimed to identify plasma metabolomic markers mediating anisocytosis with aging.

Keywords: erythrocyte anisocytosis; anisocytosis older; mediate erythrocyte; anisocytosis; markers mediate; metabolomic markers

Journal Title: Journal of Internal Medicine
Year Published: 2023

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