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Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers

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The objective of this study was to longitudinally investigate the trajectory of change in 1H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow‐up, and to determine… Click to show full abstract

The objective of this study was to longitudinally investigate the trajectory of change in 1H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow‐up, and to determine the time at which the neurochemical alterations accelerated during disease progression.

Keywords: brain spectroscopy; mutation carriers; spectroscopy changes; spectroscopy; mapt mutation

Journal Title: Journal of Neuroimaging
Year Published: 2019

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