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Microstructural Changes in the Left Mesocorticolimbic Pathway are Associated with the Comorbid Development of Fatigue and Depression in Multiple Sclerosis

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Lower reward responsiveness has been associated with fatigue in multiple sclerosis (MS). However, association of MS‐related fatigue with damage to the mesocorticolimbic reward pathway (superolateral medial forebrain bundle [slMFB]) has… Click to show full abstract

Lower reward responsiveness has been associated with fatigue in multiple sclerosis (MS). However, association of MS‐related fatigue with damage to the mesocorticolimbic reward pathway (superolateral medial forebrain bundle [slMFB]) has not been assessed. We investigated the association of fatigue and depression with slMFB damage in MS patients stratified based on longitudinal fatigue patterns.

Keywords: multiple sclerosis; fatigue; fatigue depression; microstructural changes

Journal Title: Journal of Neuroimaging
Year Published: 2021

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