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Hypoechogenicity of the raphe nuclei as a biomarker of migraine: A case‐control study, review, and meta‐analysis

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Hypoechogenicity of the raphe nuclei (hR) has been related to major depression. Comorbidity between migraine and depression is bidirectional postulating a common mechanism of serotonergic dysfunction. We aimed to investigate… Click to show full abstract

Hypoechogenicity of the raphe nuclei (hR) has been related to major depression. Comorbidity between migraine and depression is bidirectional postulating a common mechanism of serotonergic dysfunction. We aimed to investigate the association between migraine and hR and its role as biomarker of migraine‐associated depression and disease severity.

Keywords: raphe nuclei; migraine; hypoechogenicity raphe; biomarker migraine

Journal Title: Journal of Neuroimaging
Year Published: 2022

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