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Multiple sclerosis iron rim lesions are linked to impaired cervical spinal cord integrity using the T1/T2‐weighted ratio

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In multiple sclerosis (MS), iron rim lesions (IRLs) are characterized by pronounced tissue matrix damage. The T1/T2‐weighted (T1/T2w) ratio represents a postprocessing MRI approach to investigate tissue integrity, but studies… Click to show full abstract

In multiple sclerosis (MS), iron rim lesions (IRLs) are characterized by pronounced tissue matrix damage. The T1/T2‐weighted (T1/T2w) ratio represents a postprocessing MRI approach to investigate tissue integrity, but studies investigating spinal cord pathology are missing until now. The aim of this study was to characterize tissue integrity using the T1/T2w ratio in lesions and the normal‐appearing white and gray matter (NAWM, NAGM) in the spinal cord and brain in MS patients with and without brain IRLs.

Keywords: iron rim; spinal cord; integrity; multiple sclerosis; sclerosis iron

Journal Title: Journal of Neuroimaging
Year Published: 2022

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