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Improving the oral bioavailability of buprenorphine: an in‐vivo proof of concept

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The aim of this study was to improve the oral bioavailability of buprenorphine by inhibiting presystemic metabolism via the oral co‐administration of ‘Generally Recognized as Safe’ compounds, thus providing an… Click to show full abstract

The aim of this study was to improve the oral bioavailability of buprenorphine by inhibiting presystemic metabolism via the oral co‐administration of ‘Generally Recognized as Safe’ compounds, thus providing an orally administered drug product with less variability and comparable or higher exposure compared with the sublingual route.

Keywords: bioavailability buprenorphine; oral bioavailability; improving oral; buprenorphine vivo

Journal Title: Journal of Pharmacy and Pharmacology
Year Published: 2017

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