R‐flurbiprofen (R‐FP) was found to offer neuroprotective effects by inhibiting mitochondrial calcium overload induced by β‐amyloid peptide toxicity in Alzheimer's disease (AD). However, poor brain penetration after oral administration posed… Click to show full abstract
R‐flurbiprofen (R‐FP) was found to offer neuroprotective effects by inhibiting mitochondrial calcium overload induced by β‐amyloid peptide toxicity in Alzheimer's disease (AD). However, poor brain penetration after oral administration posed a challenge to its further development for AD treatment. In this study, we investigated the potential of serum albumin as nanoparticulate carriers for nose‐to‐brain delivery of R‐FP to improve its brain accumulation.
Keywords:
nose brain;
brain delivery;
alzheimer disease;
albumin nanoparticulate;
brain;
serum albumin
Journal Title: Journal of Pharmacy and Pharmacology
Year Published: 2018
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Journal Title: Journal of Pharmacy and Pharmacology
Year Published: 2018
Link to full text (if available)
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recommendations!