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Resveratrol is a naturally occurring antioxidant with therapeutic potential in prevention and treatment of neoplastic disease and other human disorders. However, net clearance of resveratrol in humans is very high,… Click to show full abstract
Resveratrol is a naturally occurring antioxidant with therapeutic potential in prevention and treatment of neoplastic disease and other human disorders. However, net clearance of resveratrol in humans is very high, mainly due to glucuronide conjugation. This leads to extensive presystemic extraction and low plasma concentrations after oral dosage. The present study evaluated the effect of probenecid, an inhibitor of glucuronide conjugation, on resveratrol metabolism in vitro.
Keywords:
resveratrol;
vitro potential;
resveratrol glucuronidation;
probenecid;
glucuronidation vitro;
potential implications
Journal Title: Journal of Pharmacy and Pharmacology
Year Published: 2019
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Journal Title: Journal of Pharmacy and Pharmacology
Year Published: 2019
Link to full text (if available)
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recommendations!