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Precision dosing‐based optimisation of paroxetine during pregnancy for poor and ultrarapid CYP2D6 metabolisers: a virtual clinical trial pharmacokinetics study

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Paroxetine has been demonstrated to undergo gestation‐related reductions in plasma concentrations, to an extent which is dictated by the polymorphic state of CYP 2D6. However, knowledge of appropriate dose titrations… Click to show full abstract

Paroxetine has been demonstrated to undergo gestation‐related reductions in plasma concentrations, to an extent which is dictated by the polymorphic state of CYP 2D6. However, knowledge of appropriate dose titrations is lacking.

Keywords: paroxetine pregnancy; dosing based; optimisation paroxetine; precision dosing; based optimisation; paroxetine

Journal Title: Journal of Pharmacy and Pharmacology
Year Published: 2020

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