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Essentials Anti‐factor (F) VIII antibody formation is a major complication in the treatment of hemophilia A. We investigated uptake of FVIII and FVIII immune complex by bone marrow derived dendritic… Click to show full abstract
Essentials Anti‐factor (F) VIII antibody formation is a major complication in the treatment of hemophilia A. We investigated uptake of FVIII and FVIII immune complex by bone marrow derived dendritic cells. Immune complex formation increased uptake of FVIII 3‐4 fold in a Fcγ receptor dependent manner. FVIII immune complex binding to Fcγ receptors may modulate immune tolerance induction.
Keywords:
immune;
uptake blood;
factor viii;
immune complex;
enhanced uptake
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2017
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Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!