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Protein disulfide isomerase (PDI) was discovered over fifty years ago as an enzyme that forms disulfide bonds in newly synthesized proteins in the endoplasmic reticulum [1]. Twenty five years ago… Click to show full abstract
Protein disulfide isomerase (PDI) was discovered over fifty years ago as an enzyme that forms disulfide bonds in newly synthesized proteins in the endoplasmic reticulum [1]. Twenty five years ago PDI was shown to be released from activated platelets [2] opening up a new field of research on extracellular functions of this enzyme. PDI was subsequently localized to the platelet surface [3] and shown to mediate platelet aggregation [4, 5]. This article is protected by copyright. All rights reserved.
Keywords:
disulfide isomerase;
protein disulfide;
strategy inhibition;
new antithrombotic;
antithrombotic strategy
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2017
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Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2017
Link to full text (if available)
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recommendations!