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The recommended dose of idarucizumab may not always be sufficient for sustained reversal of dabigatran

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Essentials Reversal of anticoagulant effects of dabigatran may occur despite application of idarucizumab. Monitoring of dabigatran level after antidote application is crucial to detect rebound. Repeated doses of idarucizumab may… Click to show full abstract

Essentials Reversal of anticoagulant effects of dabigatran may occur despite application of idarucizumab. Monitoring of dabigatran level after antidote application is crucial to detect rebound. Repeated doses of idarucizumab may be necessary in cases of massive dabigatran accumulation. Combination of antidote application and renal replacement therapy may offer additional benefit.

Keywords: idarucizumab may; dose idarucizumab; dabigatran; recommended dose; may always; idarucizumab

Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2017

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