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Essentials Spatiotemporal regulation of protein kinases during thrombus formation remains elusive in vivo. Activities of protein kinases were live imaged in mouse platelets at laser‐ablated arterioles. Protein kinase A was… Click to show full abstract
Essentials Spatiotemporal regulation of protein kinases during thrombus formation remains elusive in vivo. Activities of protein kinases were live imaged in mouse platelets at laser‐ablated arterioles. Protein kinase A was activated in the dislodging platelets at the downstream side of the thrombus. Extracellular signal‐regulated kinase was activated at the core of contracting platelet aggregates.
Keywords:
kinase;
thrombus formation;
extracellular signal;
regulated kinase;
protein kinase;
signal regulated
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2017
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Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!