Essentials The mechanisms of extracellular signal‐regulated kinase 5 (ERK5) in GPIb‐IX signaling are unclear. Function of ERK5 in GPIb‐IX was tested using aggregation, western blotting, and mass spectrometry. The protein… Click to show full abstract
Essentials The mechanisms of extracellular signal‐regulated kinase 5 (ERK5) in GPIb‐IX signaling are unclear. Function of ERK5 in GPIb‐IX was tested using aggregation, western blotting, and mass spectrometry. The protein interacting with ERK5 in human platelets was identified as casein kinase II (CKII). ERK5 associates with CKII to regulate the activation of the PI3K/Akt pathway in GPIb‐IX signaling.
Keywords:
kinase;
extracellular signal;
regulated kinase;
gpib;
casein kinase;
signal regulated
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2017
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Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2017
Link to full text (if available)
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recommendations!