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Essentials Membrane‐binding GLA domains of coagulation factors are essential for proper clot formation. Factor X (FX) is specific to phosphatidylserine (PS) lipids through unknown atomic‐level interactions. Molecular dynamics simulations were… Click to show full abstract
Essentials Membrane‐binding GLA domains of coagulation factors are essential for proper clot formation. Factor X (FX) is specific to phosphatidylserine (PS) lipids through unknown atomic‐level interactions. Molecular dynamics simulations were used to develop the first membrane‐bound model of FX‐GLA. PS binding modes of FX‐GLA were described, and potential PS‐specific binding sites identified.
Keywords:
lipid specificity;
coagulation;
membrane binding;
factor;
specificity membrane
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2017
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Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2017
Link to full text (if available)
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recommendations!