Photo by nci from unsplash
Essentials The role of von Willebrand factor (VWF) domains in regulating platelet adhesion was studied in vivo. Multimeric VWF with spacers at the N‐ and C‐terminus of VWF‐A1 were systematically… Click to show full abstract
Essentials The role of von Willebrand factor (VWF) domains in regulating platelet adhesion was studied in vivo. Multimeric VWF with spacers at the N‐ and C‐terminus of VWF‐A1 were systematically tested. N‐terminal modified VWF avidly bound platelet GpIbα, causing VWD Type2B like phenotype in mice. Novel anti‐D'D3 mAbs suggest that changes at the D'D3‐A1 interface may be biologically relevant.
Keywords:
platelet adhesion;
von willebrand;
willebrand factor
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!