Essentials The role of von Willebrand factor (VWF) domains in regulating platelet adhesion was studied in vivo. Multimeric VWF with spacers at the N‐ and C‐terminus of VWF‐A1 were systematically… Click to show full abstract
Essentials The role of von Willebrand factor (VWF) domains in regulating platelet adhesion was studied in vivo. Multimeric VWF with spacers at the N‐ and C‐terminus of VWF‐A1 were systematically tested. N‐terminal modified VWF avidly bound platelet GpIbα, causing VWD Type2B like phenotype in mice. Novel anti‐D'D3 mAbs suggest that changes at the D'D3‐A1 interface may be biologically relevant.
               
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