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Androgen receptor dampens tissue factor expression via nuclear factor‐κB and early growth response protein 1

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Essentials Androgen deprivation increases the rate of venous thromboembolism in prostate cancer patients. We characterized androgen receptor‐mediated tissue factor regulation in prostate epithelial cells. Androgen receptor is dampening tissue factor… Click to show full abstract

Essentials Androgen deprivation increases the rate of venous thromboembolism in prostate cancer patients. We characterized androgen receptor‐mediated tissue factor regulation in prostate epithelial cells. Androgen receptor is dampening tissue factor expression in prostate epithelial cells. Androgen deprivation could enhance tissue factor expression and raise venous thromboembolism rates.

Keywords: factor expression; factor; androgen receptor; tissue factor

Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2018

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