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Essentials The immunogenesis of Heparin‐induced thrombocytopenia (HIT) is not well understood. Immunization to platelet factor 4 (PF4)‐heparin occurs early in life, before any heparin exposure. PF4 and PF4‐heparin complexes induce… Click to show full abstract
Essentials The immunogenesis of Heparin‐induced thrombocytopenia (HIT) is not well understood. Immunization to platelet factor 4 (PF4)‐heparin occurs early in life, before any heparin exposure. PF4 and PF4‐heparin complexes induce the proliferation of CD14+ cells. Reduced levels of regulatory cytokines contribute to immune dysregulation in HIT.
Keywords:
heparin;
heparin complexes;
induced thrombocytopenia;
heparin induced;
platelet factor
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2018
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Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!