Photo by nci from unsplash
Coagulation factor XIII (FXIII) is a stepchild among clotting factors. As opposed to all other zymogenic clotting factors, it is not the precursor of a proteolytic enzyme but of a… Click to show full abstract
Coagulation factor XIII (FXIII) is a stepchild among clotting factors. As opposed to all other zymogenic clotting factors, it is not the precursor of a proteolytic enzyme but of a transglutaminase. It is of tetrameric structure consisting of two types of subunits (FXIII-A2 B2 ). In the final step of the coagulation cascade the A subunit (FXIII-A is transformed into an active enzyme by the concerted action of thrombin and Ca2+ . Thrombin cleaves off an activation peptide (AP-FXIII) of 37 amino acids from the N-terminal end of FXIII-A. This article is protected by copyright. All rights reserved.
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!