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Fibrinolysis in patients with chemotherapy‐induced thrombocytopenia and the effect of platelet transfusion

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Essentials Bleeding in chemotherapy induced thrombocytopenia (CIT) might be influenced by hyperfibrinolysis. t‐PA‐thromboelastography is a fast and reliable assay for hyperfibrinolysis in CIT patients. Clots of CIT patients are more… Click to show full abstract

Essentials Bleeding in chemotherapy induced thrombocytopenia (CIT) might be influenced by hyperfibrinolysis. t‐PA‐thromboelastography is a fast and reliable assay for hyperfibrinolysis in CIT patients. Clots of CIT patients are more susceptible to t‐PA induced lysis compared to healthy individuals. Besides platelets, other factors are likely to influence clot lysis in CIT patients.

Keywords: thrombocytopenia effect; patients chemotherapy; cit patients; induced thrombocytopenia; chemotherapy induced; fibrinolysis patients

Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2019

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