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Plasminogen activator inhibitor‐1 (PAI‐1), a key inhibitor of plasminogen activators (PAs) tissue‐type PA (tPA) and urokinase‐type PA (uPA) plays a crucial role in many (patho)physiological processes (e.g., cardiovascular disease, tissue… Click to show full abstract
Plasminogen activator inhibitor‐1 (PAI‐1), a key inhibitor of plasminogen activators (PAs) tissue‐type PA (tPA) and urokinase‐type PA (uPA) plays a crucial role in many (patho)physiological processes (e.g., cardiovascular disease, tissue fibrosis) as well as in many age‐related pathologies. Therefore, much effort has been put into the development of small molecule or antibody‐based PAI‐1 inhibitors.
Keywords:
two nanobodies;
plasminogen;
mechanism two;
molecular mechanism;
plasminogen activator
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2019
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Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2019
Link to full text (if available)
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recommendations!