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Essentials Elimination of PDAC tumor cell PAR1 increased cytotoxic T cells and reduced tumor macrophages. PAR1KO PDAC cells are preferentially eliminated from growing tumors. Thrombin‐PAR1 signaling in PDAC tumor cells… Click to show full abstract
Essentials Elimination of PDAC tumor cell PAR1 increased cytotoxic T cells and reduced tumor macrophages. PAR1KO PDAC cells are preferentially eliminated from growing tumors. Thrombin‐PAR1 signaling in PDAC tumor cells drives an immunosuppressive gene signature. Csf2 and Ptgs2 are thrombin‐PAR1 downstream immune suppressor genes in PDAC tumor cells.
Keywords:
thrombin par1;
par1 signaling;
pdac tumor;
par1
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2020
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Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!