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The prothrombinase complex consists of factors Xa (FXa) and Va (FVa) on an anionic phospholipid surface and converts prothrombin into thrombin. Both coagulation factors require activation before complex assembly. We… Click to show full abstract
The prothrombinase complex consists of factors Xa (FXa) and Va (FVa) on an anionic phospholipid surface and converts prothrombin into thrombin. Both coagulation factors require activation before complex assembly. We recently identified TIX‐5, a unique anticoagulant tick protein that specifically inhibits FXa‐mediated activation of FV. Because TIX‐5 inhibited thrombin generation in blood plasma, it was concluded that FV activation by FXa contributes importantly to coagulation.
Keywords:
anticoagulant tix;
function anticoagulant;
mediated activation;
activation;
tix;
structure function
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2021
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Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!