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Immune thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal thrombotic microangiopathy, resulting from a severe deficiency of plasma ADAMTS‐13 (A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motif, member 13)… Click to show full abstract
Immune thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal thrombotic microangiopathy, resulting from a severe deficiency of plasma ADAMTS‐13 (A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motif, member 13) activity. IgG‐type autoantibodies are primarily responsible for the inhibition of plasma ADAMTS‐13 activity. However, the mechanism underlying autoantibody‐mediated inhibition is not fully understood.
Keywords:
human monoclonal;
thrombotic thrombocytopenic;
adamts;
thrombocytopenic purpura;
monoclonal antibody
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2021
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Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!