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Vaccine‐induced immune thrombocytopenia and thrombosis (VITT) following ChAdOx1 nCOV‐19 vaccine has been described, associated with unusual site thrombosis, thrombocytopenia, raised D‐dimer, and high‐titer immunoglobulin‐G (IgG) class anti‐platelet factor 4 (PF4)… Click to show full abstract
Vaccine‐induced immune thrombocytopenia and thrombosis (VITT) following ChAdOx1 nCOV‐19 vaccine has been described, associated with unusual site thrombosis, thrombocytopenia, raised D‐dimer, and high‐titer immunoglobulin‐G (IgG) class anti‐platelet factor 4 (PF4) antibodies. Enzyme‐linked immunosorbent assays (ELISA) have been shown to detect anti‐PF4 in patients with VITT, but chemiluminescence assays do not reliably detect them. ELISA assays are not widely available in diagnostic laboratories, and, globally, very few laboratories perform platelet activation assays.
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2021
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