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Factor V‐Short (FV756‐1458) is a natural splice variant in which 702 residues are deleted from the B domain. It exposes an acid region (AR2; 1493–1537) that binds tissue factor pathway… Click to show full abstract
Factor V‐Short (FV756‐1458) is a natural splice variant in which 702 residues are deleted from the B domain. It exposes an acid region (AR2; 1493–1537) that binds tissue factor pathway inhibitor alpha (TFPIα). Protein S also interacts with TFPIα and serves as TFPIα‐cofactor in factor Xa (FXa) inhibition. FV‐Short and protein S function as synergistic TFPIα‐cofactors in inhibition of FXa. FV810‐1492 is an artificial FV‐Short variant that cannot synergize with protein S as TFPIα cofactor even though it contains AR2 and binds TFPIα.
Keywords:
factor short;
protein;
tfpi cofactor;
factor
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2021
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Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!