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Osteopontin (OPN) is a multifunctional proinflammatory matricellular protein overexpressed in multiple human cancers and associated with tumor progression and metastases. Thrombin cleavage of OPN reveals a cryptic binding site for… Click to show full abstract
Osteopontin (OPN) is a multifunctional proinflammatory matricellular protein overexpressed in multiple human cancers and associated with tumor progression and metastases. Thrombin cleavage of OPN reveals a cryptic binding site for α4β1 and α9β1 integrins.
Keywords:
cleavage osteopontin;
osteopontin;
osteopontin initiates;
tumor;
thrombin cleavage
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2022
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Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!