Photo from wikipedia
Factor V‐short (FV756‐1458) is a natural splice variant functioning in synergy with protein S as tissue factor pathway inhibitor alpha (TFPIα)–cofactor in inhibition of factor Xa (FXa). An exposed acid… Click to show full abstract
Factor V‐short (FV756‐1458) is a natural splice variant functioning in synergy with protein S as tissue factor pathway inhibitor alpha (TFPIα)–cofactor in inhibition of factor Xa (FXa). An exposed acid region (AR2; 1493–1537) in the B domain binds TFPIα. The preAR2 (1458–1492) is crucial for the synergistic TFPIα–cofactor activity between FV‐short and protein S and for assembly of a trimolecular FXa‐inhibitory complex among FV‐short, protein S, and TFPIα.
Keywords:
factor short;
tfpi cofactor;
tfpi;
protein
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!