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Antithrombotic potential of a single‐domain antibody enhancing the activated protein C‐cofactor activity of protein S

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Protein S (PS) is a natural anticoagulant acting as a cofactor for activated protein C (APC) in the proteolytic inactivation of activated factors V (FVa) and VIII (FVIIIa), but also… Click to show full abstract

Protein S (PS) is a natural anticoagulant acting as a cofactor for activated protein C (APC) in the proteolytic inactivation of activated factors V (FVa) and VIII (FVIIIa), but also for tissue factor pathway inhibitor α (TFPIα) in the inhibition of activated factor X (FXa).

Keywords: activated protein; potential single; domain antibody; cofactor; antithrombotic potential; single domain

Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2022

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