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Inhibition of platelet aggregation by activation of platelet intermediate conductance Ca2+‐activated potassium channels

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Within the vasculature platelets and endothelial cells play crucial roles in hemostasis and thrombosis. Platelets, like endothelial cells, possess intermediate conductance Ca2+‐activated K+ (IKCa) channels and generate nitric oxide (NO).… Click to show full abstract

Within the vasculature platelets and endothelial cells play crucial roles in hemostasis and thrombosis. Platelets, like endothelial cells, possess intermediate conductance Ca2+‐activated K+ (IKCa) channels and generate nitric oxide (NO). Although NO limits platelet aggregation, the role of IKCa channels in platelet function and NO generation has not yet been explored.

Keywords: conductance ca2; ca2 activated; intermediate conductance; platelet aggregation; platelet

Journal Title: Journal of Thrombosis and Haemostasis
Year Published: 2022

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