LAUSR

Persons who inject drugs (PWID) have been experiencing a higher burden of new hepatitis C (HCV) due to the opioid epidemic. The greatest increases in injection have been in rural communities. However, less is known about the prevalence of HCV or its risk factors in rural compared to non‐rural communities. This study compared HCV infection history, current infection, and associated behavioural and sociodemographic correlates among PWID recruited from rural and non‐rural communities from Upstate New York (NY). This cross‐sectional study recruited 309 PWID, using respondent‐driven sampling. Blood samples were collected through finger stick for HCV antibody and RNA tests. A survey was also self‐administered for HCV infection history, sociodemographics and behavioural correlates to compare by setting rurality. HCV seropositivity was significantly higher among PWID from rural than non‐rural communities (71.0% vs. 46.8%), as was current infection (41.4% vs. 25.9%). High levels of past year syringe (44.4%) and equipment (62.2%) sharing were reported. Factors associated with infection history include syringe service program utilization, non‐Hispanic white race, sharing needles and methamphetamine injection, which was higher in rural vs. non‐rural communities (38.5% vs. 15.5%). HCV burden among PWID appears higher in rural than non‐rural communities and may be increasing possibly due to greater levels of methamphetamine injection. On‐going systematic surveillance of HCV prevalence and correlates is crucial to respond to the changing opioid epidemic landscape. Additionally, improving access to harm reduction services, especially with special focus on stimulants, may be important to reduce HCV prevalence among PWID in rural settings.