LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

Association of serum calprotectin (S100A8/A9) concentrations and idiopathic hyperlipidemia in Miniature Schnauzers

Photo by gabiontheroad from unsplash

Background Idiopathic hyperlipidemia (IH) is a common condition in Miniature Schnauzers (MS). Studies in people have linked IH to low‐grade inflammation, which plays an important role in the pathogenesis of… Click to show full abstract

Background Idiopathic hyperlipidemia (IH) is a common condition in Miniature Schnauzers (MS). Studies in people have linked IH to low‐grade inflammation, which plays an important role in the pathogenesis of IH complications. The role of inflammation in MS with IH is unknown. Objective Evaluation of the inflammatory markers serum calprotectin and S100A12 in MS with IH and in response to dietary intervention for IH management. Animals One‐hundred fifty clinically healthy MS. Methods Serum triglyceride, cholesterol, calprotectin, and S100A12 concentrations were measured before and after placing the dogs on an ultra‐low fat diet. Results Hypertriglyceridemia (HTGL, P < .001) and hypercholesterolemia (HCHOL, P = .01) were independently associated with increased serum calprotectin but not S100A12 concentrations. Compared to normolipidemic MS, serum calprotectin concentrations were significantly higher in MS with HTGL (P < .001) or combined hyperlipidemia (P = .02), but not those with isolated HCHOL (P = 1.0000). Presence (P = .005) and severity (P = .003) of HTGL and serum cholesterol concentrations (P = .04) decreased in MS with IH within 14‐26 weeks after being placed on the ultra‐low fat diet, but neither serum calprotectin nor S100A12 concentrations changed significantly with this dietary intervention. Conclusions and clinical importance Subclinical (low‐grade) inflammation appears to be present in some MS with IH, and an ultra‐low fat diet does not decrease serum concentrations of inflammatory proteins in those dogs. Whether this presumed inflammatory phenotype in MS with IH is associated with the development of IH complications (eg, insulin resistance) requires further research.

Keywords: miniature schnauzers; serum calprotectin; idiopathic hyperlipidemia; calprotectin s100a12; serum

Journal Title: Journal of Veterinary Internal Medicine
Year Published: 2019

Link to full text (if available)


Share on Social Media:                               Sign Up to like & get
recommendations!

Related content

More Information              News              Social Media              Video              Recommended



                Click one of the above tabs to view related content.