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Rotational thromboelastometry can detect factor XIII deficiency and bleeding diathesis in patients with cirrhosis

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Patients with progressive liver disease exhibit complex coagulation disorders. Factor XIII plays a crucial role in the last steps of haemostasis, and its deficiency is associated with an increased incidence… Click to show full abstract

Patients with progressive liver disease exhibit complex coagulation disorders. Factor XIII plays a crucial role in the last steps of haemostasis, and its deficiency is associated with an increased incidence of bleeding diathesis. However, current conventional coagulation tests cannot detect factor XIII deficiency. In this study, we examined factor XIII activity and the ability of rotational thromboelastometry to detect factor XIII deficiency and bleeding diathesis in patients with cirrhosis.

Keywords: detect factor; xiii; factor xiii; deficiency; bleeding diathesis

Journal Title: Liver International
Year Published: 2017

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