Photo by mattmoloney from unsplash
Enhancement of host anti‐oxidant enzymes, such as haemoxygenase‐1, may attenuate virus‐mediated hepatocyte injury, while the induction of HO‐1 by cobalt‐protoporphyrin‐IX (CoPP) administration, as the application of its haem degradation product… Click to show full abstract
Enhancement of host anti‐oxidant enzymes, such as haemoxygenase‐1, may attenuate virus‐mediated hepatocyte injury, while the induction of HO‐1 by cobalt‐protoporphyrin‐IX (CoPP) administration, as the application of its haem degradation product biliverdin (BV), was shown to hinder HCV replication in vitro. In addition, (GT)n‐repeats length in the polymorphic region of the HO‐1 promoter may affect HO‐1 expression and responsiveness to infection and disease severity. Aim of this study was to investigate the antiviral and hepatoprotective effects of CoPP‐mediated HO‐1 induction, alone or in combination with interferon alpha (peg‐IFNα), in HCV‐infected mice harbouring hepatocytes from donors with different HO‐1‐promoter polymorphisms.
Journal Title: Liver International
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!