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Genetic determinants of hepatic steatosis and serum cytokeratin‐18 fragment levels in Taiwanese children

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There are substantial genetic components contributing to the susceptibility of nonalcoholic fatty liver disease (NAFLD). It has recently been reported that the rs641738 C>T variant in the membrane‐bound O‐acyltransferase domain‐containing… Click to show full abstract

There are substantial genetic components contributing to the susceptibility of nonalcoholic fatty liver disease (NAFLD). It has recently been reported that the rs641738 C>T variant in the membrane‐bound O‐acyltransferase domain‐containing protein 7 (MBOAT7) gene increased severity of NAFLD in adults of European descent. We aimed to test the hypothesis that MBOAT7 rs641738 variant would increase hepatic steatosis and hepatocellular injury in obese children.

Keywords: genetic determinants; steatosis serum; hepatic steatosis; determinants hepatic; serum cytokeratin; steatosis

Journal Title: Liver International
Year Published: 2018

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