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Sp1‐regulated transcription of RasGRP1 promotes hepatocellular carcinoma (HCC) proliferation

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The role of Ras guanine nucleotide‐releasing protein 1 (RasGRP1) in tumourigenesis has been a subject of debate, and its functions and clinical significance in hepatocellular carcinoma (HCC) remain unknown. Here,… Click to show full abstract

The role of Ras guanine nucleotide‐releasing protein 1 (RasGRP1) in tumourigenesis has been a subject of debate, and its functions and clinical significance in hepatocellular carcinoma (HCC) remain unknown. Here, we evaluated the expression of RasGRP1 in HCC and determined how it contributes to HCC cell proliferation.

Keywords: hepatocellular carcinoma; hcc; carcinoma hcc; proliferation; rasgrp1

Journal Title: Liver International
Year Published: 2018

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