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Reduction and stabilization of bilirubin with obeticholic acid treatment in patients with primary biliary cholangitis

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Total bilirubin is a predictor of survival in primary biliary cholangitis, with the main elevated component being direct bilirubin. The purpose of this post hoc analysis was to assess the… Click to show full abstract

Total bilirubin is a predictor of survival in primary biliary cholangitis, with the main elevated component being direct bilirubin. The purpose of this post hoc analysis was to assess the efficacy and safety of obeticholic acid across quartiles of varying baseline levels of direct bilirubin in the phase 3, randomized, placebo‐controlled Primary Biliary Cholangitis Obeticholic Acid International Study of Efficacy.

Keywords: primary biliary; reduction stabilization; stabilization bilirubin; obeticholic acid; biliary cholangitis

Journal Title: Liver International
Year Published: 2020

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