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Extensively expanded murine‐induced hepatic stem cells maintain high‐efficient hepatic differentiation potential for repopulation of injured livers

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Shortage of donor hepatocytes limits hepatocyte transplantation for clinical application. Induced hepatic stem cells (iHepSCs) have capacities of self‐renewal and bipotential differentiations. Here, we investigated whether iHepSCs could be extensively… Click to show full abstract

Shortage of donor hepatocytes limits hepatocyte transplantation for clinical application. Induced hepatic stem cells (iHepSCs) have capacities of self‐renewal and bipotential differentiations. Here, we investigated whether iHepSCs could be extensively expanded, and whether they could differentiate into sufficient functional hepatocytes as donors for transplantation therapy after their extensive expansions.

Keywords: hepatic stem; induced hepatic; stem cells; expanded murine; extensively expanded

Journal Title: Liver International
Year Published: 2020

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