The increased intestinal permeability, caused by chronic alcohol consumption, may result in translocation of gut microbiota-derived PAMPs or even bacteria themselves. Their arrival in liver can trigger hepatic inflammation, which… Click to show full abstract
The increased intestinal permeability, caused by chronic alcohol consumption, may result in translocation of gut microbiota-derived PAMPs or even bacteria themselves. Their arrival in liver can trigger hepatic inflammation, which exacerbates ALD2,3 . Indeed, E. faecalis colonized in the gut of alcoholic hepatitis patients can translocate through leaky intestinal barrier to liver2 .
               
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