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DLK1‐directed chimeric antigen receptor T‐cell therapy for hepatocellular carcinoma

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Delta‐like homologue 1 (DLK1), a transmembrane protein, is highly expressed in hepatocellular carcinoma (HCC). We explored whether DLK1‐directed chimeric antigen receptor (CAR) T cells can specifically eliminate DLK1‐positive HCC cells… Click to show full abstract

Delta‐like homologue 1 (DLK1), a transmembrane protein, is highly expressed in hepatocellular carcinoma (HCC). We explored whether DLK1‐directed chimeric antigen receptor (CAR) T cells can specifically eliminate DLK1‐positive HCC cells and serve as a therapeutic strategy for HCC immunotherapy.

Keywords: directed chimeric; hepatocellular carcinoma; antigen receptor; chimeric antigen; dlk1; dlk1 directed

Journal Title: Liver International
Year Published: 2022

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