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Enoxaparin attenuates pyrrolizidine alkaloids‐induced hepatic sinusoidal obstruction syndrome by inhibiting oncostatin M expression

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The definitive treatment for pyrrolizidine alkaloids (PAs)‐induced hepatic sinusoidal obstruction syndrome (HSOS) is not available. The effectiveness of anticoagulation therapy remains controversial. The efficacy of low molecular weight heparin (LMWH)… Click to show full abstract

The definitive treatment for pyrrolizidine alkaloids (PAs)‐induced hepatic sinusoidal obstruction syndrome (HSOS) is not available. The effectiveness of anticoagulation therapy remains controversial. The efficacy of low molecular weight heparin (LMWH) should be investigated in patients and animal models, and the underlying mechanism should be explored.

Keywords: sinusoidal obstruction; obstruction syndrome; hepatic sinusoidal; pyrrolizidine alkaloids; induced hepatic

Journal Title: Liver International
Year Published: 2022

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