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Cold stress‐induced bladder overactivity in type 2 diabetic mellitus rats is mitigated by the combination of a M3‐muscarinic antagonist and a β3‐adrenergic agonist

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Goto‐Kakizaki (GK) rats with type 2 diabetes mellitus respond to low temperature (LT) environments with bladder overactivity, including increased voiding frequency and decreased voiding interval and micturition volume. We determined… Click to show full abstract

Goto‐Kakizaki (GK) rats with type 2 diabetes mellitus respond to low temperature (LT) environments with bladder overactivity, including increased voiding frequency and decreased voiding interval and micturition volume. We determined if bladder overactivity could be inhibited by treatment with the combination of a M3‐muscarinic receptor antagonist and a β3‐adrenergic receptor agonist.

Keywords: antagonist adrenergic; bladder overactivity; combination muscarinic; overactivity

Journal Title: LUTS: Lower Urinary Tract Symptoms
Year Published: 2022

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