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Evidence for role of capillaries in regulation of skeletal muscle oxygen supply

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How oxygen (O2) supply to capillaries is regulated to match the tissue's demand is unknown. Erythrocytes have been proposed as sensors in this regulatory mechanism since they release ATP, a… Click to show full abstract

How oxygen (O2) supply to capillaries is regulated to match the tissue's demand is unknown. Erythrocytes have been proposed as sensors in this regulatory mechanism since they release ATP, a vasodilator, in an oxygen saturation (SO2)‐dependent manner. ATP causes hyperpolarization of endothelial cells resulting in conducted vasodilation to arterioles.

Keywords: oxygen; capillaries regulation; role capillaries; evidence role; oxygen supply

Journal Title: Microcirculation
Year Published: 2021

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