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The neonatal mouse retina is a well‐characterized experimental model for investigating factors impacting retinal angiogenesis and inner blood‐retinal barrier (BRB) integrity. Retinoic acid (RA) is an essential signaling molecule. RA… Click to show full abstract
The neonatal mouse retina is a well‐characterized experimental model for investigating factors impacting retinal angiogenesis and inner blood‐retinal barrier (BRB) integrity. Retinoic acid (RA) is an essential signaling molecule. RA is needed for vasculogenic development in embryos and endothelial barrier integrity in zebrafish retina and adult mouse brain; however, the function of this signaling molecule in developing mammalian retinal vasculature remains unknown. This study aims to investigate the role of RA signaling in angiogenesis and inner BRB integrity in mouse neonatal retina.
Journal Title: Microcirculation
Year Published: 2022
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