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Serine proteases mediate leukocyte recruitment and hepatic microvascular injury in the acute phase following extended hepatectomy

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Post‐hepatectomy liver failure (PHLF) is the main limitation of extended liver resection. The molecular mechanism and the role of leukocytes in the development of PHLF remain to be unveiled. We… Click to show full abstract

Post‐hepatectomy liver failure (PHLF) is the main limitation of extended liver resection. The molecular mechanism and the role of leukocytes in the development of PHLF remain to be unveiled. We aimed to address the impact of serine proteases (SPs) on the acute phase after liver resection by intravitally analyzing leukocyte recruitment and changes in hemodynamics and microcirculation of the liver.

Keywords: leukocyte recruitment; acute phase; serine proteases

Journal Title: Microcirculation
Year Published: 2022

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