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Eumycetoma causative agents are inhibited in vitro by luliconazole, lanoconazole and ravuconazole

Eumycetoma is a subcutaneous mutilating disease that can be caused by many different fungi. Current treatment consists of prolonged itraconazole administration in combination with surgery. In many centres, due to… Click to show full abstract

Eumycetoma is a subcutaneous mutilating disease that can be caused by many different fungi. Current treatment consists of prolonged itraconazole administration in combination with surgery. In many centres, due to their slow growth rate, the treatment for eumycetoma is often started before the causative agent is identified. This harbours the risk that the causative fungus is not susceptible to the given empirical therapy. In the open‐source drug program MycetOS, ravuconazole and luliconazole were promising antifungal agents that were able to inhibit the growth of Madurella mycetomatis, the most common causative agent of mycetoma. However, it is currently not known whether these drugs inhibit the growth of other eumycetoma causative agents.

Keywords: vitro luliconazole; inhibited vitro; causative agents; luliconazole lanoconazole; eumycetoma causative; agents inhibited

Journal Title: Mycoses
Year Published: 2022

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